In the postoperative period, about 20–80 percent of patients report moderate–to–severe pain. Thermal, mechanical, or chemically caused tissue damage are among the most common causes of postoperative pain. It is mainly nociceptive in nature. The goal of this study is to examine all techniques and medicines used for postoperative pain management, with a focus on all new developments in the treatment of postoperative pain. Methods: As you can see, it's a review of There was a search done using the following media keywords in MEDLINE, Embase, Pubmed, and CINAHL Plus in the same time period from 2000 to 2021: Articles written in languages other than English are not eligible for evaluation. Finally, the outcomes are as follows: When it comes to postoperative pain treatment, opioids are still the go-to option, but the current opioid crisis is driving doctors to explore alternative options that utilise a variety of pain management modalities. Other pain-relieving receptors in the spinal cord are targeted by these pathways instead of opioid receptors in the brain and body. When administered as a single dose, local anaesthetics, whether infiltrated locally or utilised in regional anaesthesia methods, have a short half-life. Extended postsurgical pain treatment using local anaesthetics may be achieved by utilising patient-controlled analgesia pumps or by combining them with other analgesics such as epinephrine, dexamethasone, or clonidine.