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199491

Evaluation of Bone Mineral Density in Children with Hemophilia A in Benha Insurance Hospital

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Last updated: 28 Dec 2024

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Abstract

Background; children with HA have decreased physical activity and are at higher risk for hemoarthrosis (75% to 90% of kids with HA), Hepatitis C, and other blood-borne diseases. All of these may lead to osteoporosis and a lack of vitamin D. The objective of this research was to evaluate the bone mineral density of children with haemophilia A. Methods: This case-control research was conducted on 60 people. The control group consisted of 30 instances involving haemophilia A and 30 healthy youngsters. In all patients included, comprehensive history was taken, thorough clinical review, labouratory evaluation of CBC, Ca, and vit. D and BMD were evaluated in the lumbar spinal area (L2-L4) using dual energy X-ray absorptiometry (DXA). Results: in patients (16.6 ng/ml), vitamin D3 was much lower than the controls (23 ng/ml). The value of P was <0.001. In patients (8.1 mg/dl) serum ca was considerably lower than controls (9.5 mg/dl). P-value was less than 0.001. Median DEXA z score in the case (-1.4) was much lower than controls (0.8). P-value was less than 0.001. DEXA Z score exhibited strong positive PAS relationships (r=0.730 & P <0.001), Vitamin D3 (r=0.693 & P <0.001) and ca (r =0.786 & P <0.001), while no significant connection between the DEXA Z score and the DEXA Z score exists (age, weight, height, BMI, WBCs, HCT, Hb, platelets, PT, PTT, INR). Conclusion: in hemophilic patients, vitamin D calcium and BMD were substantially reduced, and DEXA Z was shown to have strong positive associations to PAS, to vitamin D3, and approx.

DOI

10.21608/bjas.2021.199491

Keywords

bone, density, children, Hemophilia A

Authors

First Name

H.A.

Last Name

Elghaiaty

MiddleName

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Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

H.R.

Last Name

Omar

MiddleName

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Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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City

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Orcid

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First Name

H.M.

Last Name

Khater

MiddleName

-

Affiliation

Radiology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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City

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Orcid

-

First Name

S.S.

Last Name

Shehata

MiddleName

-

Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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City

-

Orcid

-

Volume

6

Article Issue

5

Related Issue

27998

Issue Date

2021-09-01

Receive Date

2021-10-14

Publish Date

2021-09-01

Page Start

209

Page End

215

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_199491.html

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https://bjas.journals.ekb.eg/service?article_code=199491

Order

34

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Evaluation of Bone Mineral Density in Children with Hemophilia A in Benha Insurance Hospital

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Article

Created At

23 Jan 2023