In this research, the effects of diabetes Milletus on the globally longitudinal strain (GLS) after ST-Segment Elevation Myocardial Infarction (STEMI) have been successfully refilled in patients throughout the period of hospital stay with the use of Speckle Tracking ECHO (STE). Methods: This trial comprised 60 patients, each group was allocated sequentially when they fulfilled the research inclusion criteria; Group (I):- which included 32 individuals with DM history or the use of oral anti-diabetic or insulin medicinal medicines or HbA1c #6.5). Methods: This group of patients is then grouped into Group (A):- containing 23 controlled DM patients (HbA1c < 7), Group (B):- including 9 un-controlled DM patients (HbA1c < 7). Then the group will be grouped into Group (A). Group (II):- Including 28 individuals without DM history, using antidiabetic medication or HbA1c < 6.5). Results & Schlussfolgerungen: GLS (GLS= -12.4) in those with managed diabetes (HbA1c < 7) was significantly greater than (GLS= -10.5) in those with uncontrolled diabetes (HbA1c = 7) in patients. The P-value was less than 0.001. GLS offers an appropriate, quick, easily accessible and reliable technique for LV dysfunction evaluation which may precede the functional changes ob-served with traditional 2D echocardiography. Higher levels of HbA1c linked with greater prevalence of LV dysfunction in diabetic patients, sessed by GLS derived speckling monitoring, even in individuals with successful reperfusion. Echocardiography.