Background:Acne vulgaris (AV): is the most frequent dermatologic illness and is the chronic, multifactoral, inflammatory disease of the pilosebaceous unit. Aim: to compare the dynamic balance between thiol/disulfide and the balance of healthy individuals in AV sufferers. Methods: This research has been performed on 40 individuals who have been clinically diagnosed with AV. Furthermore, 40 seemingly healthy people of matching sex and age are controlled. Each patient had a thorough history, a comprehensive clinical examination and a laboratory study for: Total Thiol and thiol disulphide serum level. Results & Findings: The age varied from 16 to 31 years with mean ± SD = (22.40±4.35) years, while the control age was between 16 and 31 years with mean ±SD = (23.83±4.99) years, with no significant statistical differences (p=0.288) between both groups. This age was considered to have been between 16 and 31 years. Comparative for serum total thiol, serum thiol disulfide and their ratio between the two groups examined. The serum total thiol (p < 0,001) and serum thiol disulfide (p < 0,001) in the AV group were significantly increased as compared to the control group. Although the total thiol/thiol disulfide ratio (p < 0.001) in AV group has decreased considerably compared with the control group.