Multisystem autoimmune disease SLE, which affects almost all organs and tissues, is a classic example of this kind of illness. Some researchers believe that because of the illness's great variability, SLE should be considered a syndrome rather than a single disease. In this study, the goal is to see whether urine plasmin levels may be used as a simple test and readily accessible marker in individuals with systemic lupus erythematosus. In this research, there were 50 SLE patients and 20 healthy volunteers. Urine samples were obtained and plasmin level was tested. Results showed that in SLE patients, urine plasmin levels were substantially higher than in healthy controls. Final thoughts: Urine-based biomarkers for detecting SLE patients are promising since they are noninvasive, safe, and helpful.