Background: There have been biological exaggerations of lipid production among women with preeclampsia, but the function of serum lipids in the development of preeclampsia is unclear. In women with preeclampsis, high density lipoprotein (HDL) and LDL have been found to be lower in preeclampsia when plasma concentrations of triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL) and very low density lipoprotein (VLDL) have been increased. The current research aimed at evaluating maternal and newborn serum lipid levels and their association to neonatal respiratory distress syndrome in preeclamptic females. Methods: This is a case-control research that included two identical groups of preterm infants between 28-34 weeks, with preeclampsia as pre-existing status and normotensive moms. Results: In newborn moms with pre-term labour, RD was shown to be substantially greater than women with pre-eclampsia (P<0.05). We discovered that newborns with RD of mothers with pre-eclampsia and mother with child lipid profiles had higher maternal levels of total cholesterol, triglycerides and LDL, but lower levels of HDL, although this variation remained insignificant. The cord level of LDL and triglycerides in the RDS group was nevertheless lower. Conclusion: Maternal lipid levels are an indicator for RDS prediction. In pregnancies complicated by preeclampsia, higher maternal serum lipids have been found. In children and their mothers, RDS is accompanied with lipid changes.