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198228

Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome

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Last updated: 28 Dec 2024

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Abstract

Background: The role of pro-inflammatory cytokines in the immunopathogenesis of idiopathic nephrotic syndrome (INS)  had been widely postulated. Reports on the release of cytokines, during idiopathic nephrotic syndrome activation, were conflicting in defining a specific interleukin pattern during relapse and remission of the disease. The monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family, and a potent chemotactic factor for monocytes. It plays an important role in the recruitment of monocytes/macrophages into renal tubulointerstitium . Objective: The aim of this study was to determine the urinary level of monocyte chemotactic protein-1 (uMCP-1) in idiopathic nephrotic syndrome patients and its relationship to steroid sensitivity. Patients and Methods: This cross sectional study included 40 patients with nephrotic syndrome (NS) following up in Pediatric Nephrology Clinic, Benha University subdivided into 2 groups: group A (cases in remission) & group B (cases in activity). Also, 20 age and sex matched healthy children have been included as a control group. Results:  We found a highly significant difference in urinary MCP-1 between group A, group B, and controls, the highest being group B. The levels in patients in remission still exceeded the controls significantly. No difference was found between males and females in group A as regards urinary MCP-1 levels yet females had significantly higher levels in group B. This difference was not seen in controls. Conclusions: Urinary MCP-1 is highly sensitive and specific biomarker in idiopathic nephrotic syndrome.

DOI

10.21608/bjas.2021.198228

Keywords

Idiopathic nephrotic syndrome, Urinary Monocyte Chemotactic Protein-1, relapse, Remission

Authors

First Name

A.S.

Last Name

El hamshary

MiddleName

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Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

O.M.

Last Name

Abdel Haie

MiddleName

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Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

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Orcid

-

First Name

W.E

Last Name

Afifi

MiddleName

-

Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

-

Orcid

-

First Name

A.A.

Last Name

El Falah

MiddleName

-

Affiliation

Clinical and Chemical Pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

-

Orcid

-

First Name

A.R.

Last Name

Mohammed

MiddleName

-

Affiliation

Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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City

-

Orcid

-

Volume

6

Article Issue

5

Related Issue

27998

Issue Date

2021-09-01

Receive Date

2021-10-05

Publish Date

2021-09-01

Page Start

51

Page End

54

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_198228.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=198228

Order

9

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome

Details

Type

Article

Created At

23 Jan 2023