Objective: Despite reduced systemic toxicity compared to other medicines, hydroxychloroquine is a widely used immunosuppressive agent for the treatment of different autoimmune disorders. It may induce serious retinal impairment and blindness. The purpose of this research is to evaluate the early OCT results in preclinical retinopathy of hydroxychloroquine (HCQ). Patients and procedures: This cross-sectional comparative study has taken place in ophthalmology and rheumatology clinics in Benha university hospitals; twenty eyes of rheumatic HCQ patients for over two years and 20 eyes of ordinary gender patients have been examined and imaged fully with spectrum optic coherence tomography (SD-OCT). The whole research group had a normal look of a fundus. Results: For more than two years of usage with still normal fundus, external retinal dilation as central foveal and parafoveal dilution was observed with SD-OCT in individuals with chronic HCQ. In just 2 rheumatic individuals the IS/OS junction was disrupted (10 percent ). Only three rheumatic patients suffered from colour vision (15 percent ). Conclusion: Preclinical HCQ retinopathy may be detected in the screening of SD-OCT rheumatic patients, particularly with the increasing availability of SD-OCT machinery in most visual centres