Background: Chronic idiopathic polyneuropathy is asymmetrical, axonal damage involving large fibres of insidious onsets is disclosed in neurophysiologic long-dependent neuropathy and slowly progressive course over a minimum of six months without aetiology can be identified despite the appropriate investigations. This research was designed to investigate idiopathic polyneuropathy individuals. Methods: The comparative patient control research comprised 20 patients selected from 127 polyneuropathic and 20 matching age or sex controls from the Al-Azhar University Neurology Clinic at Assuit Hospitals, April 2019 to May 2021. Results: Age of onset of idiopathic polyneuropathy patients (47-73), length of disease (1-6) years (60%), DN4 score (5–7), abnormal pine brick (80%), abnormal vibrations (90%), abnormal fine touch (75%), distal weaknesses (70%) losing ankle (90%) and wasting (20 percent ). This represents significant variations in the amplitude of decreased motor-action compounds and the reduced speed of median,ulnar, tibial peroneal nerves across the tested groups. Significant variations between tibial and peroneal tissues are also seen in prolonged distal latency, decreased sensory amplitude and extended latency between sensory (median, ulnar, and sural) nerves. The delay differences and a reduced amplitude of sympathetic cutaneous response across the investigated groups are significant. There are also substantial differences in the intraepidermal nerve fibre density decrease in skin biopsy from the distal leg between idiopathic polyneuropathical patients and control groups. Conclusion: Intraepidermal nerve fibre density in skin biopsy is responsive to idiopathic polyneuropathy than standard neurophyological investigations.