Human sexuality is the way people express themselves as sexual beings.  This involves biological, erotic, physical, emotional, social or spiritual feeling and behaviors. Sexual dysfunction refers to a problem occurring during any phase of the sexual response cycle that prevents the individual or couple from experiencing satisfaction during the sexual activity .  The aim of this work is to assess the sexual function of the male partners of females with chronic hepatitis c virus. This was a cross sectional study that was conducted on 100 males (<45 years old) married to sexually active female partners having chronic hepatitis C (group A) and 100 age matched males married to healthy individuals as control (group B) all subjects were recruited from Banha University Hospital (hepatology unit) and National Liver Institute at EL-Menofia during the period from January 2017 to December 2018. Data was collected using the International Index of Erectile Function (IIEF) questionnaire. we noticed that males married to female partners who receive treatment of HCV had high scores of sexual functions than males married to untreated female partners regarding to all items of sexual domains of IIEF (p < 0,001). The results of this study provide quantifiable risk information for counseling long-term monogamous heterosexual couples in which one partner has chronic HCV infection. In addition to the extremely low estimated risk for HCV infection in sexual partners, the lack of association with specific sexual practices provides unambiguous and reassuring counseling messages.