A black eye circle or periorbital hyperpigmentation affects men and women alike. The periocular area is affected by a poorly defined lesion that appears as round or semicircular brown or dark brown pigmented macules. VEGFA (rs833061) and P53 (rs1042522) polymorphisms were detected in various periorbital hyperpigmentation types. Methods: Thirty patients with periorbital hyperpigmentation were included in this prospective case-control research, along with twenty seemingly healthy control individuals of the same age and gender. The distribution of p53 and VEGFA genotypes in patients and controls did not vary significantly. Cases with POH were more likely to have p53 genotypes Pro/Pro and Arg/Pro+Pro/Pro than controls. A greater frequency of the VEGFA TC, CC, TC+CC genotypes, and the C allele were found in patients compared to the control group with POH risk. The VEGFA TC genotype was associated with the pigmented subtype. Periorbital hyperpigmentation was more likely to occur in those with the p53-pro/pro and arg/pro+pro/pro genotypes, the pro allele, VEGFA-TC, TC+CC, and C allele genotypes. There was a strong association between the VEGFA TC genotype and the pigment subtype. Otherwise. There was no relationship between VEGFA rs833061 and any of the VEGFA variants (p53 rs1042522 or p53 rs1042522). For orbital hyperpigmentation susceptibility, P53 and VEGFA genotypes have been proposed as risk factors.