Introduction: The global prevalence of chronic hepatitis C, Hepatitis B, alcoholic-related and non-alcoholic-related fatty hepatitis liver disease has increased. In cardiovascular patients, severe liver failure raises the likelihood of complications including heart, kidney and lung infections and increases the burden of postoperative care. Work aim: to estimate the prevalence of peri-operative morbidity and death in cirrhotic patients and their determinants. Methods: This controlled cross-sectional research evaluated 30 cirrhotic patients who have been undergoing heart chirurgy as controls, as opposed to 30 non-cirrhotic patients. Results: After heart surgery, the mortality rate was 20%, which was much higher than non-cirrhotic post-cardiac surgery 3% (p = 0.04). The association between death rates and ALT, AST and PCR (p = 0.008, 0.01, 0.02 correspondingly) was positive. There has also been a significant negative connection between death rate and AFP level (p=0.01). Conclusion: organ-related dysfunctions are critical for developing post-CS problems and adverse outcomes. ALT, AST, AFP and PCR are important indicators of cirrhotic patient death after heart surgery.