Objectives: The objective of this research was to assess as a predictor of Preterm labour, the usefulness of serum ferritine levels. Data Sources: This research was a case-control study performed from May 2020 to February 2021 by the department of gynaecology and obstetrics at the Benha University Hospital. Study selection: 90 pregnant women of 28 to 35 weeks in premature work or with premature work risk factors (history of previous preterm, vaginal bleeding in pregnancy, moderate to severe anemia, short cervix, cervical incompetence, previous cervical surgery, submucosal uterine fibroid, substance abuse during pregnancy) Findings: the ROC curve indicates that serum ferritin level off point 220 ng/ml was chosen with a sensitivity equal to 61.54%, a specificity of 92.19%, a positive PPV of 76.2%, a negative predictive value (NPV) of 85.5%, and an accuracy of 70 percent. Conclusion: The optimum cut-off was significantly increased in serum ferritin concentrations linked with spontaneous preterm delivery and serum ferritin levels of more than 220 ng/mL.