Background: Acne vulgaris is a prevalent chronic skin condition with pilosebaceous blockages and/or inflammation (hair follicles and their accompanying sebaceous gland). Aim: to investigate vaspin levels in serum of acne sufferers in comparison with normal controls and to link their levels with the severity of the illness. Methods: 30 instances of AV and 31 healthy control groups have been examined and each patient has been submitted to comprehensive history; complete clinical examination and levels of serum vaspine were calculated. Methods: Results: The level of vaspin was much greater in the AV group than the control group (medium=2785.2 vs 155.4 against p < 0.001). For discriminating between AV patients and control groups, the Vaspin level receiver operating characteristic curve (ROC) has been performed. Vaspin exhibited o.989 AUC. At a cut-off of 212.2, sensitivity was 96.7%, the specificity of 96.8%, 96.7%, NPV was 96.7% and the accuracy of 96.8%. ROC Vaspin-level curve has been performed for discriminating between mild to moderate and severe AV patients. Vaspin exhibited o.93o AUC. At a cut-off value of 3,911.5, sensitivity was 9%, the specificity was 9%, PPV was 81.8%, NPV was 94.7%, and accuracy was 9%. Conclusion: The level of Vaspin in the AV group was considerably greater than that of the control group with 96.7% susceptibility and 96.8% characteristics. Adipose and severity of AV were linked substantially with a greater vaspin level; the Vaspin level was proposed as a separate AV susceptibility and severity predictor.