Background: Immune thrombocytopenia (ITP) is an autoimmune disorder associated with decreased platelet production and accelerated platelet destruction lead to thrombocytopenia and mucocutaneos bleeding.  It is usually a benign, self-limiting disease in children. An impaired immune system may be associated with ITP.  objectives: The aim of this study was to assess the level IL-17 among active patients in relation to control. Subjects and methods : This study was a case-control study. The study included 20 patients with acute ITP. The patients were recruited from Pediatric hematology outpatient clinics and departments, Benha University Hospitals. In addition, 20 healthy children of comparable age and sex were taken as controls. Informed consents were obtained. Results: There was no statistically significant difference between cases and control regarding HB and WBCs but value of platelets was significantly  lower among cases than control. . IL -17 level was Significantly higher in ITP cases when compared to control groups . Conclusion: This study concluded that, IL-17  may contribute to the pathogenesis of ITP. It could be potential biomarker that diagnose and predict the clinical course of ITP.