History: Peptide is a 42-amino acid peptide hormone involved in glucose control. It entailed energy balance and regulation of the metabolism of glucose and fatty acids. Its shortcoming raised the danger of IR. The sensitivity to insulin and gestational mellitus diabetes (GDM) are tightly linked. Peptide may thus also affect the aetiology of GDM. Goals: The present research aimed at detecting the function of peptide and metabolism in pregnant women. Method: 60 pregnant patients with a pregnancy-related pruritus (Group A) with 30 years of matching healthy pregnancy controls were tested for this research (Group B). The research eliminated all participants with the following conditions: any pruritus classified as a particular dermatological disorder (urticaria, dermatitis, psoriasis, bite, scars and scabies), diabetic, hepatic and hypertensive patients. The liver function, blood glucose level and lipid profile were assessed in all individuals. The amount of serum peptide has been determined by means of commercially available immunosorbent assay kits. Results: Pruritus pregnant women had substantially greater eosinophilic numbers and immunoglobulin E (Ig E) (P respectively 0.05) than control group. In comparison to the control group, the total, direct bilirubin, bile acid, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) (P>0.05 each, were not substantially higher for pregnant women with pruritus. and substantial positive lipoprotein (HDL) connection (P value = 0.012), but not connected to age in the pregnancy-related group with Pruritus. 33.3% of the patients investigated experienced mild itching, 45% had moderate irritation, and 21.7% had severe irritation. Conclusion: Our data imply that serum levels might be regarded as independent predictors of the sensitivity, activity and severity of pruritus associated with the pregnancy.