Hepatitis B is a dangerous illness and simple blood transportation and other ways, particularly in patients with chronic hemodialysis (HD). HBV has significant pathogenicity and mortality rates. The objective of this experiment was to assess the rates of anti-HBc distribution among chronic HD patients in Hodeidah City. This investigation was applied to 150 chronic HD patients and soon before HD sessions, samples were obtained. All samples have been analysed using ELISA for anti-HBc. Sera, which has shown that anti-HBc is positive, were tested for liver function. The ages of 30 to 50y (40,7 percent) were the most vulnerable and statistically significant to the HD process (P < 0,05). Of 150, 129 (86.0 percent) were anti-HBcAg positive. Conclusions: significant anti-HBc distribution rate among HD patients in the city of Hodeidah.