A wart is a noncancerous growth that may arise in the skin and mucosa. These are benign lesions caused by human papillomavirus (HPV), and over 100 different strains of HPV have been found. Prevalent warts, genital warts, flat warts, deep palmoplantar warts, localised epithelial hyperplasia, epidermodysplasia verruciformis, and plantar cysts are the most common ways that infection manifests. In individuals with genital warts or who are immunocompromised, malignant transformation is often found. While oxidative stress is an intriguing and mostly unexplored option in HPV-mediated carcinogenesis, further investigation is needed. Aim: The goal of this research is to find out whether levels of Nuclear factor-erythroid 2-related factor 2 (Nrf2) are associated to cutaneous warts in Egyptian patients and whether there is a relationship between Nrf2 levels and the severity of the disease. Objectives and Processes: Enzyme-linked immunosorbent assay was used to detect the amounts of Nrf2 in 25 patients with warts and 25 healthy controls (ELISA). Warts are correlated with Nrf2 levels, and these levels were shown to be greater in patients with warts (P =0.001). The most likely conclusion is that higher levels of Nrf2 indicate a role in the development of warts.