The genes TLX 1 and TLX 3 as two genes of the Hox gene family have been selected in this review. Such genes have been shown to have a certain function in malignancies, including acute lymphoblastic T cell leukaemia (T-ALL). The principal phases of the research involved extraction of DNA as well as gene sequence of normal and ill cases. This thesis included partial examination of the above two genes in T-cell Both patients for adults and infants. Further analyses were performed using bioinformatic tools to establish the variation in the secondary structure of mRNA. The key knowledge was obtained that the proposed protein products had physicochemical properties in relation to the secondary structure of mRNA. Finally, the variation in samples compared with standard controls will influence the stability of these protein products. This knowledge will serve both as a disease detector and in connection to patients with a relapse.