Plants have been used since ancient times in folk medicine, involving all medical traditions. Many plants and plant derived antimicrobial components are used in folklore therapeutics for oral hygiene. Salvia officinalis and Aloe vera extracts were assayed for the evaluation of their antimicrobial activity against two pathogenic bacteria that were identified biochemically and by VITEK2 system. The test of antibiotic susceptibility showed the resistance of the two isolates to at least ten antibiotics used in this study. In vitro investigations of nine Egyptian plant extracts showed that ethanolic Aloe vera and ethanolic Salvia officinalis extracts could exhibit an antibacterial activity against human pathogenic isolates and inhibition zones of 16.333±0.58 and 13.0 ±1.0 mm were observed when Salvia officinalis extract applied against the above-mentioned bacteria, while the inhibition zones of 13.333±0.58 and 11.667±0.58 mm were observed by Aloe vera extract.