Warts (verrucas) are an extremely common, benign, and usually self-limited skin disease. Infection of epidermal cells with the human papillomavirus (HPV) results in cell proliferation and a thickened, warty papule on the skin. The aim of this study was to evaluate serum levels of  Interleukin 17 in patients with verrucas,correlate their levels with different demographic and clinical data. Method: This present study included: patient group(1) included 30 verruca patients. In addition,15apparently healthy, age and sex matched individuals included as a control group (Group 2). All patients were selected from outpatient clinic of Dermatology ans Andrology department of Benha University Hospital from Jan 2020 t0 July 2020. Informed consents were obtained from all participants. The study was approved by the local ethics committee on research involving human subjects, Faculty of Medicine , Benha University. Results and conclusion:  it is concluded that IL 17 levels are lower in verruca patients than controls.