Psoriasis is resistant interceded persistent and repetitive, fiery dermatosis skin infection. netrin 1 has a significant part in the pathogenesis of a few immune system sicknesses. This examination is intended to assess the conceivable job of Netrin 1 in the pathogenesis of psoriasis by estimating its level in the serum of psoriatic patients and associate its level with the seriousness. which may help later on treatment of psoriatic injury. This examination included 60 patients experiencing psoriasis vulgaris . Furthermore, 30 obviously solid people of coordinated with age and sex will be picked as a benchmark group. All patients will be exposed to finish history, complete general and dermatological clinical assessment will be finished. Assessment of serum level of netrins 1 in patients and control bunches by ELISA. By contrasting the two gatherings of patients and controls in this investigation there was a huge reduction in the mean serum level of Netrin1 in psoriatic patients contrasted and controls. There was high critical positive connection between's PASI score (seriousness of disease)and level of infection ,while there was no huge relationship between's PASI score and illness span or age. There was high huge negative connection between's Netrin1 level and degree likewise there was critical negative relationship between's Netrin1and Disease span while there was no huge relationship between's Netrin 1 and age and sex. There is a part of Nerrin1 in the pathogenesis of psoriasis.Netrin1 can be utilized as marker of sickness degree and illness length.