The etiology of psoriasis stays indistinct, in spite of the fact that there is proof for hereditary inclination. The part of the resistant framework in psoriasis causation is likewise a significant subject of examination. The point of the current investigation was to assess serum levels of netrin 1 protein in patients with psoriasis and it's relationship with sickness seriousness Patient and strategies: A cross area case control study was led on ninety subjects ordered into two gatherings: Patient gathering: Sixty patients grumbling of psoriasis vulgaris. Control gathering: Thirty clear solid age and sex coordinated with individual . Psoriasis seriousness was assessed by PASI score. All read subjects were tried for Serum level of nertin 1 by compound connected immunosorbent measure (ELISA). Results: There was high critical negative relationship between's Netrin1 level and degree additionally there was huge negative connection between's Netrin1and Disease term while there was no huge connection between's Netrin 1 and age and sex Conclusion: There is a job of Nerrin1 in the pathogenesis of psoriasis.Netrin1 can be utilized as pointer of sickness degree and infection length.