To evaluate serum level of Tenascin C in vasculogenic erectile brokenness patient and its relationship. Erectile brokenness (ED) is industrious failure to accomplish or keep up inflexible penile erection adequate for agreeable sexual execution. ED is viewed as of vascular beginning in by far most of the patients. Tenascin C protein (TN C) has an immediate job in vascular occlusive redesigning with deferred neointimal arrangement. Tenascin C can be considered as a potential biomarker in obsessive conditions portrayed by tissue injury and fibrosis. This examination included 80 Participants partitioned into two gatherings; bunch I included 50 patients determined by penile Doppler to have psoriasis and gathering II included 30 ( age and sex coordinated) evidently sound volunteers as a control. serum level of TN-C was estimated utilizing ELISA method in ED patients and contrasted with control bunch The consequences of our examination uncovered that patients had high measurably huge higher TN-C (p < 0.011) than control group.