Vitiligo is a common, acquired pigmentary disorder of unknown etiology, affecting up to 0.1–2% of the population worldwide. Interleukin-23 (IL-23) is a cytokine which is believed to have an important role in the pathogenesis of autoimmune diseases. The aim of our study was to investigate the association between IL-23 (þ2199A/C) receptor gene polymorphism and vitiligo pathogenesis. This was a case control study which included 50 patients suffering from vitiligo (Group A). In addition to 50 apparently healthy individuals of matched age and sex had been chosen as a control group (Group B). Each patient was subjected to full history taking, complete clinical examination, and Laboratory investigations for serum level of Il23 receptor gene. The mean age of studied cases was 30.8 years. They were 16 males (32%) and 34 females (68%). In addition, 50 apparently healthy individuals of matched age and sex was added as a control group (P>0.05). Taking rs10889677 CC as the reference genotype and C as the reference allele; AA genotype and A allele showed significantly higher frequency  when compared to control groups (p=0.024, 0.049 respectively), with risk to develop vitiligo. BSA%, disease duration, frequency of progressive disease increased gradually, while age of disease onset decreased gradually according to CC, CA, and AA respectively. The rs10889677 AA genotype and A allele showed significantly higher frequency in cases when compared to control groups with risk to develop vitiligo cases.