Vitiligo is an obtained pigmentary turmoil of the skin and mucous films. Interleukin-12 has a positive synergistic proliferative impact on pre-initiated NK and T cells, improves freely and additionally synergistically the cytolytic capacity of both NK and CD8+ T cells by upregulation of qualities that encode cytotoxic cell granule-related proteins. The point of the work is to uncover the relationship between IL-12 quality polymorphism and vitiligo pathogenesis among contemplated gathering of Egyptian populace. This case-control study included 50 patients experiencing vitiligo (Group A) and 50 obviously solid people of coordinated age and sex as a benchmark (Group B). All patients were exposed to the followings: Full history taking, Clinical assessment, and Laboratory examinations for the genotypes of interleukin-12 (1188 A/C) SNP. Results and Conclusion: The IL12B rs3212227 CC genotype and C allele indicated fundamentally lower recurrence in situations when contrasted with control bunches with defensive impact to create vitiligo cases. Negative family ancestry, non-smokers and CC genotype were viewed as defensive indicators against vitiligo powerlessness. More seasoned period of beginning, more limited illness term, CA and CC genotypes were viewed as free indicators of less extreme vitiligo patients. By and by, bigger examinations are as yet expected to affirm our discoveries and to research the function of - 12 hereditary polymorphism in sickness seriousness.