Custodiol cardioplegia is appealing for insignificantly intrusive heart medical procedure, as a solitary portion gives a significant stretch of myocardial insurance. In spite of far and wide use in Europe, there is little information affirming its viability contrasted and regular (blood or crystalloid) cardioplegia. We pointed in this examination to set up a correlation among old and most recent methods of cardioplegia with respect to preferences and burdens of both. An imminent accomplice study directed in Cardiothoracic Department, Benha University Hospital during the time frame from March 2018 to May 2020 and included 120 patients of cardiovascular medical procedure which requires cardioplegia and cardiopulmonary detour partitioned into two gatherings: bunch An included 60 patients who got custodial while bunch B included 60 patients who got customary cardioplegia.Our result demonstrated that in gathering the mean EF inside 3 and a half year post-employable (58.8 and 57.9 separately) while in gathering B (58.1 and 57.6 individually) with no measurably distinction. Left ventricular end systolic pressing factor in gathering B post-employable 6 m (2.7) was lower than that of gathering A (3.5) and there was critical factual distinction (P esteem =0.006 post 6 m). While postoperative discharge portion in the two gatherings indicated unimportant measurable distinction. The utilization of Custodiol is helpful, straightforward, protected and more compelling than monotonous intentionally and without hesitation cardioplegia in ensuring the myocardium in complex cardiovascular tasks particularly postoperative inotropic underpins, ICU stay and emergency clinic stay periods.