Warts are common viral infections of the skin and mucous membranes that are caused by the human papilloma virus (HPV). Warts are prevalent worldwide. Recently, immunotherapy with intralesional antigens or vaccines has been tried for the treatment of common warts with encouraging results. It could lead to resolution without any physical changes or scarring and in addition would augment the host response against the causative agent. The aim of this study is to evaluate the effect of intralesional injection of MMR vaccine with intralesional injection of  saline in patients with viral warts. This study was carried out in Dermatology, Venereology and Andrology Department Outpatients Clinics, Benha University Hospitals.This study included 38 patients with viral warts.18 patients were injected with MMR vaccine while 20 patients were injected with saline as control.Approval of Dermatology, Venereology and Andrology Department and Ethics Committee in the Faculty of Medicine, Benha University was taken before preceding the study. Written consent was taken from all participants involved in this study. Comparing between response obtained after MMR injection and saline injection in  control group revealed significantly better response in MMR group when compared to control groups (p < 0.001 for each).14 patients (77.8%) reached complete response after MMR injection while no patient responsed to saline injection. No significant association was found regarding response of mother warts to recurrence in all studied cases' groups. MMR injection showed significantly better response of mother wart when compared to control group. MMR injection showed significantly better response of other warts when compared to control group.