Progesterone is required for successful conception to suPPort the endometrium for blastocyst after implantation and continuation of pregnancy. During IVF cycles, the endometrium and embryo are exposed to supra-physiological concentrations of estradiol and progesterone during ovarian stimulation, which could influence pregnancy outcomes.Study design : this is a prospective observational study included 140 patients underwent ICSI as a treatment of infertility. This study was conducted in private center for ICSI, during period from March 2018 to February 2020. The study analysed the relationship between serum progesterone concentration on the day of HCG administration and IVF pregnancy rate in gonadotrophin-releasing hormone agonist protocols. mean progesteron in pregnant was (0.9+0.2) & in non pregnant was (2.1+0.6), the pregnant cases had alower level of progesterone compared to non pregnant group with significant difference in between by using unpaired t-test. positive correlation between progesterone versus number of retrieved and fertilized oocytes by using Spearman correlation, no significant correlation versus other variables.  According to our study we found that an increase in serum progesterone levels on the day of HCG administration in GnRH agonist protocol was detrimental to IVF pregnancy outcome by reducing clinical pregnancy.