The organ dysfunction defined as an increase in the Sequential (Sepsis-related) Organ Failure Assessment (SOFA) score or ≥2, and this was associated with a 10% mortality risk. The aim of the presented study was to Use of qSOFA as a useful predictor of sepsis and evidence of multiorgan failure in critically ill patients in and Comparing the predictive value of qSOFA score with that of SOFA score and APACHE II in sepsis and outcome in critically ill patient .This was a prospective comparative study that was conducted on 100 patients with sepsis and evidence of Multi-Organ Failure (MOF) with clinical suspicion of infection to evaluate the quick Sequential Organ Failure Assessment score for predicting Outcome in septic patients. Following admission all patients were subjected to the following: The quick sequential organ failure assessment (qSOFA) Score (day0 and day1). The acute physiology and chronic health evaluation II “APACHE II" (day0). The sequential organ failure assessment (SOFA) Score (day1, 3and day7). qSOFA utilization on admission was significantly related to the higher mortality as well as APACHE II and SOFA-1, SOFA-3 and SOFA-7, Estimated mortality by qSOFA-1 was the higher than qSOFA 0.qSOFA > 1 is a specific for predicting in-hospital mortality as a cut off value with 78% sensitivity, 86% specificity and highly significant p value of < 0.01.The SOFA is a superior prognostic tool for predicting mortality and organ failure than qSOFA among sepsis patients admitted to the ICU.