Vitiligo is a procured depigmentation issue including around 1-2% of populace overall ignoring age, race and sexual orientation. Prolactin is a chemical discharged by lactotrop cells in pituitary organ. PRL appears to have extra capacities in skin science and hair follicle development also. The point of this examination was to assess serum levels of Prolactin (PRL) in patients with vitiligo in contrast with sound control and to survey its relationship with prolactin quality polymorphism and vitiligo seriousness. This forthcoming case-control study was led on forty patients grumbling of vitiligo, and forty age and sex coordinated sound volunteers. Patients were enlisted from outpatient facility of Dermatology, Venereology and Andrology Department of Benha University Hospitals.There was non-huge contrast among patients and control bunches with respect to age, BMI, SBP, DBP, sex or uncommon propensities. There was non-huge distinction as respect serum PRL in patients bunch contrasted with control gathering. In patients gathering, PRL quality polymorphism demonstrated non-critical connection with sex, exceptional propensities and family ancestry. In patients gathering, PRL quality polymorphism indicated non-critical relationship with age, SBP, DBP, serum PRL, term of vitiligo and VASI score. While it demonstrated a huge connection with BMI. In patients gathering, serum PRL indicated non-huge relationship with age, BMI, SBP, DBP, term of vitiligo and VASI score.