During past three decade, HbA1c has been utilized as a biomarker for assessing glycemic control and there is a need to give effortless, basic and acceptable new substitute screening strategies for DM so we intended to assess 𝛼-2-Macroglobulin in Saliva as marker for glycemic control in sort 2 diabetic patients. This cross sectional examination included all out number of 90 subjects that were ordered into 3 gatherings bunch 1with sort 2 DM with HbA1c levels more than or equivalent to 7% gathering 2with sort 2 DM with HbA1c levels under 7% gathering 3healthy people as a benchmark group with fasting plasma glucose under 100 mg/dl, 2 h plasma glucose under 140 mg/dl, and HbA1c under 5.7%.all the included cases were exposed to estimation of salivation - 2-Macroglobulin.there was high factually huge distinction between the three groupsaccording to level of salivary α2 macroglobulinThere was measurably critical moderate positive relationship between's 𝛼-2-Macroglobulin with every one of FBG, 2Hr PPBG and HBA1C. With the upsides of quick, available, financially savvy, and noninvasive technique, salivary A2MG is a promising organic marker for glycemic control in patients with type 2 DM.