Meconium aspiration syndrome (MAS) is complex respiratory disease of the term and near-term neonate, which keeps on putting a significant weight on neonatal escalated care assets around the world. The point of this examination was appraisal of high recurrence oscillatory ventilation versus traditional ventilation in administration of neonatal meconium desire, Method: This imminent randomized controlled preliminary included 50 infants admitted to NICU with meconium yearning (MAS), were isolated into 2 gatherings: Group 1: 25 cases treated by customary mechanical ventilation (CMV), Group 2: 25 cases treated by high-recurrence oscillatory ventilator (HFOV). All included patients were exposed to full history taking, total clinical assessment, and research center appraisal. Changes in the oxygenation work markers was utilized for checking patients' reaction as: Fraction of motivation O2 (FiO2), Oxygenation list (OI), blood vessel oxygen pressure/alveolar blood vessel oxygen strain (a/ApO2), at 2, 12, 24, 48 h of treatment. Results: This investigation included 27 guys (54%) and 23 females (46%), the mean gestational age was 37.82±2.6 weeks, CMV gathering, had a measurably longer span of ventilation time (CMV: 7.24±0.65 days, HFOV: 4.23±1.37 days, p < 0.001), longer oxygen treatment (CMV: 15.39±2.44 days, HFOV: 11.76±5.32 days, p < 0.001), and longer season of hospitalization (CMV: 22.17±4.53 days, HFOV: 17.92±12.6 days, p < 0.001). End: Our outcomes demonstrated that HFOV seems to offer extra favorable circumstances contrasted with CMV in the treatment of MAS, by lessening the length of mechanical ventilation, and span of hospitalization, anyway it didn't influence the death rate.