Neonatal sepsis is one of the leading causes of morbidity and mortality among term and preterm infants worldwide.assessment of the changes in cerebral blood flow velocity [CBFV] in cases of the neonatal sepsis.This study including 100 infants. 60neonates are diagnosed with neonatal sepsis [Sepsis group].while the other 40 neonates with no signs of neonatal sepsis [Control group]. Trans-cranial Doppler [TCD] was carried out for assessment of blood flow velocity in the anterior [ACA] and middle cerebral arteries [MCA] Peak systolic velocity [PSV], end diastolic velocity [EDV], and resistive index [RI] were measured.RI and PI were significantly decreased, with mean RI 0.56in MCA & Median RI in ACA 0.59 & Median PI 0.98; 0.98 in MCA & ACA respectively in the case group, while with a mean RI 0.75 in MCA & Median RI 0.72 in ACA respectively & Median PI1.35; 1.27 in MCA & ACA respectively .Whereas the Peak systolic velocity was increased with a mean of 69.07 in MCA & Median of 66.4 in ACA respectively in case group & mean of 50.22; in MCA & Median of 44.0 in ACA in control group with p value <0.001 in MCA & ACA respectively. neonatal sepsis causes increase in Peak systolic velocity & decrease in the Resistive & Pulsatility index thus causing increase in the cerebral blood flow, which in turn showed increased incidence in Intraventricular hemorrhage .