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165724

Biochemical Effect of Damperidone on Cardiac Functions after Induction of Peptic Ulcer in Albino Rats

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Last updated: 28 Dec 2024

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Abstract

The objective of the present study was to evaluate the biochemical effect of Domperidone on the cardiac functions after induction of peptic ulcer on albino rats. Sixty white male albino rats, average body weight 200- 250 gm and 12-16 weeks old were used in the experimental investigation of the study. Rats were randomly divided into two large groups Group A consist of thirty rats divided into three subgroups (subgroup G1,G2,G3) and this group is completely healthy without ulcer induction receiving Domperidone three times per day half an hour before meal each sub group receives a different dose using subgroup G1 as control. Group B consist of thirty rats undergo stomach ulcer induction and it is divided in to three subgroup (subgroup G4,G5,G6) receiving Domperidone three times per day half an hour before meal with different doses according to the subgroup. Blood samples were collected for biochemical examination three times during the study after one week, two weeks and four weeks. Tissue specimens where taken from heart for histopathological examination. We found elevated levels of Troponin (cTnT), CK-MB, LDH, and AST in groups treated with high doses of Domperidone and results was time dependent. Histopathological examination of heart showing coagulative necrosis, swollen, vacuolated myocytes with disruption and hyperesinophilia

DOI

10.21608/bjas.2017.165724

Keywords

domperidone, CK-MB, (cTnT), Stomach ulcer

Authors

First Name

M.K.

Last Name

Mahfouz

MiddleName

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Affiliation

Biochemistry and Clinical Biochemistry Dept., Faculty of Veterinary Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

S.A.

Last Name

Mostafa

MiddleName

-

Affiliation

Pathalolgy Dept., Faculty of Veterinary Medicine, Benha Univ., Benha, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Amen

MiddleName

-

Affiliation

Pathalolgy Dept., Faculty of Veterinary Medicine, Benha Univ., Benha, Egypt

Email

-

City

-

Orcid

-

First Name

A.

Last Name

Abd El-Baky

MiddleName

-

Affiliation

Pharmacology Dept., Faculty of Veterinary Medicine, Benha Univ., Benha, Egypt

Email

-

City

-

Orcid

-

First Name

N.

Last Name

Nagy

MiddleName

-

Affiliation

Pharmacology Dept., Faculty of Veterinary Medicine, Benha Univ., Benha, Egypt

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-

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-

Orcid

-

Volume

2

Article Issue

2

Related Issue

23370

Issue Date

2017-03-01

Receive Date

2021-04-22

Publish Date

2017-03-01

Page Start

83

Page End

89

Print ISSN

2356-9751

Online ISSN

2356-976X

Article File

BJAS_Volume 2_Issue 2_Pages 83-89.pdf

PDF . 877.3kB

Link

https://bjas.journals.ekb.eg/article_165724.html

Detail API

https://bjas.journals.ekb.eg/service?article_code=165724

Order

11

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Biochemical Effect of Damperidone on Cardiac Functions after Induction of Peptic Ulcer in Albino Rats

Details

Type

Article

Created At

23 Jan 2023