This study was conducted to evaluate the effects of different feed additives (Organic acids, Prebiotics and Enzymes) on economic and productive efficiency for two different broiler breeds. A total of 264 healthy unsexed one-day-old broiler chicks (Cobb and Indian River (IR) breeds) were allocated randomly in to eight groups (33 chicks/each group). Each group consists of three replicates (11 chicks/each replicate). Our results clarified that the value of final body weight of Cobb breed was the highest for organic acid (OA) treated group (2176.5187gm) and the lowest value was for prebiotics treated group (1985.14gm), while control group of (IR) breed showed the highest body weight (2238.87gm) and the lowest value was for prebiotics treated group (2086.27gm). Cobb group treated with organic acid showed higher body weight than IR group treated with organic acid. the lowest feed cost was found for OA and prebiotic groups of Cobb breed, and the best total return was found for control group of IR breed and OA group of Cobb breed, Concerning net profit value it was higher for control group of (IR) breed than the control group of Cobb breed (L.E 17.71and 15.47 respectively), and the lowest net profit value was for prebiotics treated group for both Cobb and (IR) breed respectively (L.E 13.50 and 15.28). From our results, it would be concluded that organic acid was better than other used feed additives, and they had an important role in improving economic and productive efficiency of Cobb broiler Chicks'.