187132

Bone Densitometry in Children with Idiopathic Nephrotic Syndrome

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Last updated: 05 Jan 2025

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Abstract

Childhood nephrotic syndrome (NS) is defined by nephrotic-range proteinuria, generalized edema, hypoalbuminemia, and hyperlipidemia with normal renal function. Dual-energy X-ray absorptiometry (DXA) is a two-dimensional imaging technology developed to assess bone mineral density (BMD) of the entire human skeleton.The aim of our study to assess bone mineral density among pediatrics with idiopathic nephrotic syndrome undergoing corticosteroids treatment.This study was a cross sectional study, which was done on 30 cases with idiopathic nephrotic syndrome undergoing corticosteroids treatment (at Nephrology clinic pediatric department Benha University Hospital) in the period from January 2019 till June 2019, the other group formed of 25 children with age and sex matched to the first group and apparently healthy, considered as a control group. The following investigations were done (serum creatinine, blood urea nitrogen (BUN), phosphorous (P),calcium (total and ionized; Ca),alkaline phosphatase (ALP), parathyroid hormone (PTH).BMD was measured. There was highly statistically significant increase in PTH, Ph, and ALP among Cases than Controls. There was statistically significant decrease in Ca among Cases than Controls. There was highly statistically significant decrease in z score, BMD and BMC among Cases than Controls. Patients with INS would have BMD deficits when compared to their peers. Osteopenia and osteoporosis assessed by DXA was frequent in children with INS.Bone mineralization was negatively affected by steroid treatment in children with INS.

DOI

10.21608/bjas.2019.187132

Keywords

Bone Mineral Density, Idiopathic nephrotic syndrome, children

Authors

First Name

M.S.

Last Name

Selem

MiddleName

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Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

S.A.

Last Name

Elgendy

MiddleName

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Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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City

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Orcid

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First Name

W.A

Last Name

.Afify

MiddleName

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Affiliation

Pediatrics Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

Email

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Orcid

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First Name

E.M.

Last Name

Sweid

MiddleName

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Affiliation

Radiology Dept.,Faculty of Medicine, Benha Univ., Benha, Egypt

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City

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Orcid

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First Name

M.S.

Last Name

Abdel Menem

MiddleName

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Affiliation

Tukh Hospital, Ministry of health, Egypt

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Volume

4

Article Issue

1

Related Issue

23361

Issue Date

2019-03-01

Receive Date

2019-08-03

Publish Date

2019-03-01

Page Start

127

Page End

134

Print ISSN

2356-9751

Online ISSN

2356-976X

Link

https://bjas.journals.ekb.eg/article_187132.html

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https://bjas.journals.ekb.eg/service?article_code=187132

Order

23

Type

Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

Bone Densitometry in Children with Idiopathic Nephrotic Syndrome

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Article

Created At

23 Jan 2023