CAD is mainly due to atherosclerosis, an inflammatory process that is based on the interaction between immune mechanisms and metabolic risk factors. Abnormal lipid levels, particularly elevated low-density lipoprotein [LDL-C] and decreased high-density lipoprotein [HDL-C], as well as higher level of inflammatory markers especially high sensitive CRP [hsCRP] are well-established risk factors for cardiovascular disease [CVD].The present work aims to study the relation between lipid profile, high sensitive C-reactive protein[hs-CRP] with coronary plaque characteristics as assessed by Multi slice Coronary CT angiography. Two hundreds and twenty patients presented with typical chest pain were evaluated by MSCT coronary angiography for assessment of calcium score , characters of atherosclerotic plaques as well as identification of vulnerable plaques.Lipid profile and hs-CRP were measured for those patients.