Atopic dermatitis, commonly called atopic eczema were considered to be a one sort of persistent and backsliding provocative sicknesses of skin with high heterogeneity and heritability. The principle point of this examination was to research the relationship between Paroxonase 1 quality 192Q/R and 55L/M polymorphisms and atopic dermatitis. Subjects and techniques: This was an imminent case-control study included 100 patients experiencing atopic dermatitis (AD) (Group A). Notwithstanding 100 obviously solid people of coordinated age and sex as a benchmark (Group B). Discovery of single nucleotide polymorphism (SNP) for paroxonase 1 quality (192 Q/R and 55 L/M) was finished utilizing explicit preliminaries by a polymerase chain response - based limitation section length polymorphism (PCR-RFLP) test .Results: L allele demonstrated fundamentally higher recurrence in AD patients when contrasted with control gatherings; with danger to grow AD. While 192Q/R RR, RQ+RR genotypes, R allele; 55L/M MM, ML+MM genotypes, M allele had lower recurrence in AD patients when contrasted with control gatherings. End: The QL haplotype was altogether connected with danger of AD. Further examination utilizing the rules and all the more fittingly fueled investigations ought to incredibly improve the trust in the gauge of danger factors and an impact of a specific way to deal with treatment.