Schizophrenia (SZ) is an ongoing mental issue portrayed by certain (e.g., pipedreams and fancies) ,negative (e.g., indifference and disabled inspiration), and psychological symptoms(e.g., lackluster showing in leader fu/nctions and consideration). S100B protein has been one of the most habitually examined proteins in schizophrenia. A few examinations have highlighted an expected part of s100B in SZ ,with most investigations detailing modified fringe levels of s100B when contrasted and sound controls,the point of this work is to decide serum level of S100B in an example of intense schizophrenic patients. Additionally to analyze the serum levels of s100B in schizophrenic patients and solid controls and to examine a potential relationship between's them. This scientific (case control) study included fifty patients intense schizophrenia and a comparative number of typical sound people as control gathering. The two gatherings were exposed to a semi organized meeting, SCID,PANSS and serum level of s100B.