The term fundamentally sick youngster doesn't allude to a specific illness yet it alludes to any kid who is in a clinical state which may bring about respiratory or heart failure or cut off neurologic complexities if not perceived and treated expeditiously. The point of this postulation wass to decide the scope of serum cortisol and urinary Vanillyl Mandelic Acid (VMA) levels in a gathering of basically sick kids and correspond them to seriousness and result. This cross sectional examination included 40 pediatric patients going from 1month to 18years Acute Physiology and Chronic Health Evaluation II(APACHE II) scoring framework which depends on deviations from typical of 11acute physiologic variablesAll patients had been researched for Assessment of cortisol level (ELISA) and VMA leve. Mean APACHE II score was essentially higher in non-survivors (20) contrasted with 12 in non-survivors. Middle Cortisol level was essentially higher in non-survivors (50) contrasted with survivors (20). Middle VMA was altogether higher in non-survivors (41) contrasted with survivors (10). Cortisol and VMA levels are raised in non-survivors contrasted with survivors. We recommend that the accompanying admonitions be borne as a main priority when diagnosing adrenal inadequacy in the basically sick patient.