Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis. The aim of this study was to evaluate the serum level of IMA in patients with AV to evaluate its role in AV pathogenesis and its possible relation with oxidative stress markers in the disease.This study was conducted as a case-control study and was conducted on 30 patients suffering from AV (Group A) and 18 apparently healthy individuals of matched age and sex as a control group (Group B). All studied subjects were tested for Serum level of Ischemia modified albumin (IMA), Serum level of Glutathione-S-Transferase (GST), Serum level of Catalase (CAT) and Serum level of Malondialdehyde (MDA). Serum IMA showed significant positive correlation with GAGS, GSH, MDA and significant negative correlation with CAT. AV grades showed significant positive correlation with GSH, MDA, IMA and significant negative correlation with CAT. No significant correlations were found in IMA with age and duration in AV group Serum IMA then MDA, GSH and CAT might play a role in AV pathogenesis. Moreover, its serum levels could be considered as independent predictor of AV susceptibility, activity and severity.