Retinopathy of Prematurity is an issue of the preterm infant portrayed by neurovascular interruption in the juvenile retina that may cause visual hindrance and visual deficiency. This examination planned to build up a screening device for early postnatal forecast of Retinopathy of Prematurity (ROP) in preterm infants dependent on danger factors inside the principal 48h of postnatal life. This examination was led on 200 preterm children admitted to NICU , Benha college Hospital and Nasser General Hospital in Shobra. All children were exposed to full history taking and complete clinical assessment. Fundus assessment by roundabout ophthalmoscope and computerized imaging of chosen cases were finished. There was critical factual increment of ROP among lower GA and BW (P<0.001). There was critical measurable increment of ROP in prematures with maternal history of chorioamnionitis and antenatal steroids adminstration (P<0.001). There was huge factual increment of ROP among youngsters with sepsis (P<0.001). The frequency of ROP in our investigation was 4.5%. Both birth weight at cutoff point <1.5 Kg and gestational age at cutoff point <33.5 wks had high affectability and particularity in expectation of ROP.