A few past examinations have researched the relationship between factors identified with Metabolic disorder and Androgenetic alopecia. Osteopontin capacities as a favorable to incendiary cytokine where Osteopontin can balance the resistant reaction by upgrading articulation of T aide cytokines and extracellular grid corrupting catalysts. The point of the current investigation was to assess serum Osteopontin level in patients with androgenetic alopecia and appraisal of its clinical criticalness according to metabolic condition segments.This investigation was led on 50 patients experiencing AGA (Group A) notwithstanding 30 evidently sound patients of coordinated age and sex as a benchmark (Group B). Serum Osteopontin and FBS and lipid profile were estimated in all subjects. Mean serum level of Osteopontin in patients' gathering was higher than in control gathering and the thing that matters was measurably huge. There was a factually critical distinction among patients and control bunches with respect to serum level of FBS, fatty substances and LDL cholesterol. Additionally, serum fatty substances level was essentially higher in male than female patients. Serum osteopontin level was fundamentally emphatically associated with BMI, FBS, serum complete cholesterol and serum LDL levels which mirrors its conceivable function in pathogenesis of metabolic problems in AGA patients.