Anti-toxin opposition of Helicobacter pylori (H. pylori) to treatment is going up. The clarithromycin obstruction is the serious issue of treatment disappointment in H. pylori disease .There is a basic need to decide the ebb and flow paces of such obstruction before authoritative treatment.We intended to decide antimicrobial opposition paces of H. pylori and impacts of point transformations during the 23S rRNA quality in H. pylori on clarithromycin opposition among the Egyptian populace, as a necessary advance prior to starting treatment.Fifty patients with H. pylori-positive ongoing gastritis were analyzed. H. pylori was distinguished by H.pylori stool antigen and microbiological refined of gastric biopsy . Absolute DNA was extricated from gastric biopsy examples and A2142G and A2143G transformations were recognized by PCR-limitation section length polymorphism (PCR-RFLP).H. pylori obstruction rates to clarithromycin , metronidazole, amoxicillin, and antibiotic medication were 54%, 28%,20% and 4% respectively.Additionally, for clarithromycin point changes in 23S rRNA types A2142G and A2143G of H. pylori were surveyed by PCR-RFLP measure, freak qualities were discovered to be 92.6 % of clarithromycin obstruction. A2143G change was recognized in 74.1% of tests and A2142G transformation in 18.5%. There was a solid relationship among MICs and point transformations in 23S rRNA gene.A2143G change was unmistakable . H. pylori conveying A2142G change indicated significantiy more elevated levels of MIC values for Clarithromycin anti-microbial. PCR-RFLP has uncovered a solid test permitting a fast identification of clarithromycin-obstruction. This is helpful in our nation where there is high pervasiveness of clarithromycin-obstruction prior to picking ideal treatment for H. pylori destruction.