Psoriasis vulgaris is a chronic inflammatory skin condition, associated with both a physical and a psychological burden . psoriasis is portrayed by erythematous plaques covered with slivery scales over the extensor surfaces, scalp, and lumbosacral locale . Neuregulin-1β (NRG-1) is a layer bound or discharged development and separation factor that intercedes its activity by official to ErbB receptors . The point of our work is to evaluate serum level of neuregulin1-β in psoriatic patients, trying to clarify its part in the sickness pathogenesis and its connection with the illness seriousness and its connection to cardiovascular capacity, foundational and pneumonic hypertension in psoriatic patients. Case control study included 40 patients with psoriasis (Group A). What's more 40 clearly sound controls of coordinated age and sex (Group B). Finding of psoriasis was made based on the patient's set of experiences and the ordinary clinical highlights. Serum NRG-1 levels estimated by chemical connected immunosorbent test (ELISA) . We found that complete psoriasis bunch demonstrated essentially higher serum NRG-1 when contrasted with control gathering , and NRG-1 expanded bit by bit with expanded seriousness of psoriasis . No critical contrasts were found in serum NRG-1 fixation as per sex, smoking and hypertension . NRG-1 indicated huge positive relationship with PASI and seriousness; huge positive connection with pneumonic course systolic weight (PASP) ; critical negative relationship with launch division (EF).