Liver dysfunction plays a significant role in the Intensive Care Unit [ICU] patients' morbidity and mortality. Metabolic, hemodynamic and incendiary components contribute in liver harm. Hemorrhagic stun. The examination planned to evaluate the rate of liver brokenness in neonatal emergency unit patients in pediatric office. This investigation was planned examination which led on 150 cases in Neonatal emergency unit Benha youngsters clinic which is a shut multidisciplinary optional NICU during the examination which was a half year [1/7/2018 – 31/12/2018]. All included patients were exposed to the accompanying: History taking, assessment and Laboratory examinations included Liver capacity tests including: Patients with hepatic friendship were characterized as the individuals who had any raised transaminases or cholestatic jaundice or hepatomegly dependent on clinical assessment and research center outcomes. Liver brokenness happened in 45 [30%] of the examined gathering. There were no factually critical distinction between Patients with hepatic warmth and Patients without hepatic fondness with respect to Sex. The death rate among cases was 14%. There was no factually critical distinction between Patients with hepatic fondness and Patients without hepatic love with respect to result. Liver brokenness are normal in NICU speaking to around 33% of cases.Key words: Liver dysfunction- neonates intensive care unit- incidence.