Toxemia (PE) is characterized as new-beginning hypertension creating following 20 weeks' incubation with at least one of the accompanying: proteinuria, maternal organ brokenness (counting renal, hepatic, hematological, neurological complica‌tions), as well as fetal development restriction.Aim and destinations: The point of this examination was to think about serum levels of IL-27 between preeclamptic ladies with obviously solid pregnant and non-pregnant women.Methods: One hundred and twenty females went to Gynecology and Obstetrics office and outpatient facility, Benha University Hospitals were partitioned into three gatherings; understanding gathering: included 40 pregnant ladies with PE, typical pregnant gathering: included 40 females with ordinary pregnancy and non-pregnant gathering: included 40 evidently sound non-pregnant female.Results: Serum IL-27 was essentially higher in toxemia cases more than the sound pregnant and non-pregnant controls (P < 0.001). End: Serum IL-27 might be helpful in determination of pregnant ladies compilicated by toxemia.