137320

The Effect of Bariatric Surgery on GLP-1, Insulin Resistance and Metabolic Parameters in Patients with T2DM

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Last updated: 05 Jan 2025

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Abstract

The surgical treatment of obesity improves metabolic abnormalities in patients with type 2 diabetes. The aim of this study was to evaluate the immediate and late effect of bariatric surgery on GLP-1, metabolic parameters and insulin resistance in patients with T2DM.Methods fifty patients with T2DM ,obese at levels II and III(BMI more than or equal to 35) were evaluated for BMI, WC, BP, PPGLP-1, fasting plasma glucose, fasting insulin and HOMA-IR before, 1w and 3m after intragastric ballon insertion , RYGBP and SG and evauated for Lipid profile, HbA1C, ALT and AST before and 3m after. The study demonstrated significant increase of PPGLP-1 after RYGBP and SG with better results in RYGBP .No significant change noted after IGB insertion. The metabolic parameters significantly improved in the 3 groups with best results in RYGBP group then SG group followed by IGB group.Our data suggest that the RYGB and SG surgeries,beyond weight loss, induces early beneficial changes in PPGLP-1which favor glycemic control in type 2 diabetes.Keywords RY gastric bypass. SG sleeve gastrectomy.IGB intra gastric ballon.Type 2 diabetes. GLP-1 glucagon like peptide.

DOI

10.21608/bjas.2020.137320

Authors

First Name

A.A.

Last Name

Hefni

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Affiliation

Internal Medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

M.Y.

Last Name

Seddik

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Affiliation

Internal Medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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First Name

M.S.

Last Name

Saleh

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Affiliation

Internal Medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

A.M.

Last Name

Al-Badawy

MiddleName

-

Affiliation

Internal Medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Orcid

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First Name

R.Y.

Last Name

Abd-Elkhalik

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-

Affiliation

Internal Medicine Dept., Faculty of Medicine, Benha Univ., Benha, Egypt

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Volume

5

Article Issue

Issue 7 part (1) - (2)

Related Issue

20337

Issue Date

2020-10-01

Receive Date

2020-01-09

Publish Date

2020-10-01

Page Start

37

Page End

41

Print ISSN

2356-9751

Online ISSN

2356-976X

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https://bjas.journals.ekb.eg/article_137320.html

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https://bjas.journals.ekb.eg/service?article_code=137320

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8

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Original Research Papers

Type Code

1,647

Publication Type

Journal

Publication Title

Benha Journal of Applied Sciences

Publication Link

https://bjas.journals.ekb.eg/

MainTitle

The Effect of Bariatric Surgery on GLP-1, Insulin Resistance and Metabolic Parameters in Patients with T2DM

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Article

Created At

23 Jan 2023