The aim of the present study is to evaluate the serum level of IL-19 in patients with Vitiligo to assess its role in Vitiligo.The present study will include 50 patients suffering from Vitiligo(GroupA). In addition,30 apparently healthy individuals of matched age and sex will be chosen as a control group (Group B). All patients will be selected from the outpatient clinic of Dermatology and Andrology Department of Benha University Hospitals. Estimation of serum levels Serum IL-19 levels will be measured using an ELISA kits. Five milliliters of venous blood sample will be collected from every participant in the study under complete aseptic precautions in the plain test tubes without anticoagulant.After coagulation, samples will be centrifuged (at 1500 g for 15 min). The separated serum will bealiquoted and stored at −20°C for subsequent assay of IL-19.The collected data will be tabulated and statistically analyzed using Special statistical methodsThe aim of the present study is to evaluate the serum level of IL-19 in patients with Vitiligo to assess its role in Vitiligo pathogenesis and its relation with studied disease parameters